Cardiomegaly: Causes, Symptoms and Treatment

What is Cardiomegaly?

Cardiomegaly is essentially an enlargement of the heart. This enlargement can be due to a variety of reasons and is often a response to certain stressors or conditions that place an increased demand on the heart. The heart, being the vital organ that it is, adapts to these demands by increasing in volume. This increase can be either through myocardial hypertrophy, which refers to the thickening of the heart walls, or through the dilation of the atrial and ventricular cavities.

The Causes of Cardiomegaly

Cardiomegaly can either be congenital, meaning it is present from birth, or it can develop over time due to a variety of pathological conditions that affect the heart. Some of these conditions include heart attacks, alterations in heart rhythm such as chronic tachycardia or uncontrolled atrial fibrillation, valve insufficiency, heart infections, and inflammation of the heart.

Other conditions that can lead to cardiomegaly include arterial hypertension, coronary artery disease, and certain metabolic alterations. The condition can also be a symptom of various infectious diseases, nutritional disorders, anemia, renal insufficiency, and certain genetic disorders.

In some cases, cardiomegaly can result from morbid obesity, various thyroid conditions, diabetes mellitus, and certain endocrine tumors. There are also instances where cardiomegaly is idiopathic, meaning no clear cause can be found, or reversible, such as in the case of pregnancy, stress, or intense and prolonged training.

Certain toxic substances, especially alcohol, organic solvents, drugs and some medications, can also damage the heart muscle and lead to cardiomegaly.


Cardiomegaly can be asymptomatic, meaning it presents no obvious signs or symptoms. However, when symptoms do appear, individuals can experience the following set of symptoms:

  • Fatigue, as the enlarged heart struggles to pump blood efficiently, leading to decreased circulation.
  • Shortness of breath, especially during physical activity or when lying down.
  • Swelling in the legs, ankles, or abdomen can occur due to fluid retention.
  • Palpitations or an irregular heartbeat reflecting the heart's struggle to maintain a regular rhythm.

These symptoms, if present, should prompt prompt medical evaluation to identify the underlying causes of cardiomegaly and initiate appropriate treatment.

Diseases Associated with Cardiomegaly

Cardiomegaly can be a common or probable symptom of a wide range of diseases. Some of the common causes include atherosclerosis, coronary artery disease, diabetes, heart attack, hypertension, and ventricular hypertrophy.

Rare causes of cardiomegaly include conditions such as acromegaly, AIDS, amyloidosis, anemia, rheumatoid arthritis, atrial septal defect, hemochromatosis, kidney failure, respiratory failure, adrenal insufficiency, hyperthyroidism, hypothyroidism, systemic lupus erythematosus, and thyroid cancer among others.

The symptoms of cardiomegaly are often characteristic and include dyspnea (difficulty breathing), palpitations, asthenia (weakness), peripheral edema (swelling in the legs and ankles), arrhythmias, and chest pain. It is important to note that cardiomegaly always results in a state of circulatory decompensation. In severe and progressive cases, a heart transplant may be necessary.

Diagnosing Cardiomegaly

Diagnosing cardiomegaly involves a thorough physical examination and various diagnostic tests such as chest X-ray, electrocardiogram, echocardiogram, stress test, CT scan, nuclear magnetic resonance imaging, blood tests, and cardiac biopsy via catheterization.

These investigations aim to establish the characteristics of the enlarged heart and what caused it. Understanding the causes is crucial for planning the right treatment.

Treatment Options

The treatment for cardiomegaly is largely dependent on the underlying cause of the condition. Current treatment options include pharmacological therapies for less serious cases and medical-surgical interventions for more severe cases.

Pharmacological therapy can involve the administration of diuretics, ACE inhibitors, angiotensin receptor blockers, digoxin, anticoagulants, beta blockers, and other antiarrhythmics.

If drug therapy proves ineffective or the patient's condition worsens, more invasive medical-surgical interventions may be required. These can include the installation of a pacemaker or an implantable cardioverter defibrillator (ICD), valve surgery, coronary bypass, the insertion of a ventricular assist device, or, in the most severe cases, a heart transplant.

Prevention Strategies

Preventing cardiomegaly involves maintaining a healthy lifestyle and keeping risk factors under control. This can include eating a balanced diet, engaging in regular physical activity, avoiding smoking and drug use, moderating alcohol intake, and undergoing regular cardiological check-ups, especially for those with a family history of certain cardiac disorders.

In conclusion, cardiomegaly is a complex condition with various causes and potential complications. It requires careful diagnosis and treatment planning. By understanding the condition and its implications, individuals can make informed decisions about their health and take proactive steps towards prevention.

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The Wellyme Team

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